3. Giornata
25.09.2021 15:00 Ethnikos Piräus Ethnikos Piräus - AO Proodeftiki AO Proodeftiki 2:4 dr
25.09.2021 15:00 Aris Soudas Aris Soudas - Diagoras FC Diagoras FC
26.09.2021 14:00 OFI Ierapetra OFI Ierapetra - Kalamata Kalamata 3:4 dr
26.09.2021 15:00 PAS Acheron Kanalakiou PAS Acheron Kanalakiou - Olympiakos Volou Olympiakos Volou 2:1 dts
26.09.2021 15:00 AO Edessaikos AO Edessaikos - Kozani FC Kozani FC 1:3
26.09.2021 15:00 AE Lefkimmis AE Lefkimmis - Apollon Pontou Apollon Pontou 2:1 dts
26.09.2021 15:00 Poseidon Nea Michaniona Poseidon Nea Michaniona - Levadiakos Levadiakos 0:5
26.09.2021 15:00 Thiseas Agria Thiseas Agria - Panserraikos Panserraikos 2:4 dr
26.09.2021 15:00 PO Fikis PO Fikis - Niki Volou FC Niki Volou FC 0:1
26.09.2021 15:00 Panagriniakos Panagriniakos - AO Trikala AO Trikala 0:2
26.09.2021 15:00 Ethnikos Sochos Ethnikos Sochos - AO Ypatou AO Ypatou 0:1
26.09.2021 15:00 PAO Rouf PAO Rouf - Ergotelis Ergotelis 0:3
26.09.2021 15:00 AO Neas Artakis AO Neas Artakis - AE Kifisias AE Kifisias 1:2
26.09.2021 15:00 AO Giouchtas AO Giouchtas - Agios Nikolaos Agios Nikolaos 1:2 dts
26.09.2021 15:00 Diagoras Vrachneikon Diagoras Vrachneikon - Panachaiki GE Panachaiki GE 0:1
26.09.2021 15:00 Kallithea GS Kallithea GS - AO Episkopi AO Episkopi 2:1 dts
26.09.2021 15:00 Ilioupoli GS Ilioupoli GS - Asteras Vlachioti Asteras Vlachioti 2:0
26.09.2021 15:00 AE Karaiskakis AE Karaiskakis - Xanthi FC Xanthi FC 0:2
26.09.2021 15:00 Apollon Lárissa Apollon Lárissa - AE Lárissa AE Lárissa 0:3
26.09.2021 15:00 Pierikos Katerini Pierikos Katerini - PO Triglias PO Triglias 1:2
26.09.2021 15:00 Veria FC Veria FC - Anagennisi Karditsa Anagennisi Karditsa 0:1 dts
26.09.2021 15:00 Thesprotos Thesprotos - Almopos Arideas Almopos Arideas 1:2
29.09.2021 15:00 AO Egaleo AO Egaleo - PAE Chania PAE Chania -:-