Gruppo A
23.02.2021 14:00 Simba SC Simba SC - Al-Ahly Al-Ahly
23.02.2021 14:00 Al-Merrikh SC Al-Merrikh SC - AS Vita Club AS Vita Club
06.03.2021 14:00 Al-Merrikh SC Al-Merrikh SC - Simba SC Simba SC -:-
06.03.2021 20:00 Al-Ahly Al-Ahly - AS Vita Club AS Vita Club -:-
Gruppo B
24.02.2021 14:00 Al Hilal Omdurman Al Hilal Omdurman - TP Mazembe TP Mazembe
28.02.2021 14:00 CR Bélouizdad CR Bélouizdad - Mamelodi Sundowns Mamelodi Sundowns
05.03.2021 20:00 CR Bélouizdad CR Bélouizdad - Al Hilal Omdurman Al Hilal Omdurman -:-
06.03.2021 14:00 TP Mazembe TP Mazembe - Mamelodi Sundowns Mamelodi Sundowns -:-
Gruppo C
23.02.2021 14:00 Petro Atlético Petro Atlético - Wydad AC Wydad AC
23.02.2021 17:00 Kaizer Chiefs Kaizer Chiefs - Horoya AC Horoya AC
06.03.2021 17:00 Kaizer Chiefs Kaizer Chiefs - Petro Atlético Petro Atlético -:-
06.03.2021 20:00 Wydad AC Wydad AC - Horoya AC Horoya AC -:-
Gruppo D
23.02.2021 17:00 Teungueth FC Teungueth FC - Zamalek Zamalek
23.02.2021 20:00 MC Alger MC Alger - Espérance de Tunis Espérance de Tunis
06.03.2021 17:00 Teungueth FC Teungueth FC - MC Alger MC Alger -:-
06.03.2021 17:00 Espérance de Tunis Espérance de Tunis - Zamalek Zamalek -:-