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| A | Luis Angel Firpo | - | Águila | 0:2 (0:0) | ||
| R | Águila | - | Luis Angel Firpo | 1:0 (1:0) | ||
| A: 13.01.2021 22:30 | R: 16.01.2021 22:30 | Vincitore: Águila | ||||
| A | Once Municipal | - | Alianza | 1:2 (1:2) | ||
| R | Alianza | - | Once Municipal | 3:1 (1:1) | ||
| A: 13.01.2021 22:30 | R: 17.01.2021 22:00 | Vincitore: Alianza | ||||
| A | Jocoro FC | - | Municipal Limeño | 0:0 (0:0) | ||
| R | Municipal Limeño | - | Jocoro FC | 1:2 (1:1) | ||
| A: 14.01.2021 22:15 | R: 17.01.2021 21:30 | Vincitore: Jocoro FC | ||||
| A | Sonsonate FC | - | FAS | 0:1 (0:1) | ||
| R | FAS | - | Sonsonate FC | 2:2 (2:1) | ||
| A: 15.01.2021 02:00 | R: 17.01.2021 22:00 | Vincitore: FAS | ||||
